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Burton E Sobel Selected Research

Plasminogen Activator Inhibitor 1

12/2013Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes.
10/2013The efficacy and tolerability of azilsartan in obese insulin-resistant mice with left ventricular pressure overload.
11/2011Modulators of induction of plasminogen activator inhibitor type-1 in HepG2 cells by transforming growth factor-β.
8/2011The angiotensin receptor blocker, azilsartan medoxomil (TAK-491), suppresses vascular wall expression of plasminogen activator inhibitor type-I protein potentially facilitating the stabilization of atherosclerotic plaques.
5/2010Increased expression of plasminogen activator inhibitor type-1 (PAI-1) in HEPG2 cells induced by insulin mediated by the 3'-untranslated region of the PAI-1 gene and its pharmacologic implications.
1/2010Comparison of plasminogen activator inhibitor-1, tissue type plasminogen activator antigen, fibrinogen, and D-dimer levels in various age decades in patients with type 2 diabetes mellitus and stable coronary artery disease (from the BARI 2D trial).
3/2009A profibrotic effect of plasminogen activator inhibitor type-1 (PAI-1) in the heart.
8/2008Impact of statins on modulation by insulin of expression of plasminogen activator inhibitor type-1.
8/2007Deleterious effects of lack of cardiac PAI-1 after coronary occlusion in mice and their pathophysiologic determinants.
10/2006Hepatocyte growth factor regulates E box-dependent plasminogen activator inhibitor type 1 gene expression in HepG2 liver cells.
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Burton E Sobel Research Topics

Disease

21Myocardial Infarction
07/2015 - 01/2002
14Coronary Artery Disease (Coronary Atherosclerosis)
01/2016 - 06/2002
14Insulin Resistance
08/2011 - 02/2003
12Type 2 Diabetes Mellitus (MODY)
01/2016 - 08/2002
12Inflammation (Inflammations)
08/2011 - 01/2004
10Atherosclerosis
11/2012 - 08/2002
9Fibrosis (Cirrhosis)
10/2013 - 08/2004
8Cardiovascular Diseases (Cardiovascular Disease)
01/2016 - 06/2002
8Infarction (Infarctions)
11/2010 - 01/2002
6Heart Failure
10/2013 - 02/2006
5Hyperglycemia
08/2011 - 12/2002
5Hemorrhage
12/2010 - 05/2004
4Obesity
12/2013 - 08/2004
4Hypertension (High Blood Pressure)
05/2013 - 04/2004
4ST Elevation Myocardial Infarction
08/2012 - 12/2004
4Thrombosis (Thrombus)
08/2011 - 06/2003
4Atherosclerotic Plaque (Atheroma)
08/2011 - 07/2002
4Acute Coronary Syndrome
10/2009 - 10/2002
4Coronary Occlusion
06/2009 - 08/2007
3Hypoxia (Hypoxemia)
08/2016 - 12/2013
3Ischemia
05/2013 - 11/2007
3Rupture
08/2011 - 10/2002
3Chest Pain (Chest Pains)
10/2009 - 06/2004
3Heart Diseases (Heart Disease)
06/2009 - 09/2005
3Dyslipidemias (Dyslipidemia)
09/2007 - 02/2003
3Chronic Kidney Failure (Chronic Renal Failure)
06/2007 - 08/2002
3Diabetes Mellitus
02/2006 - 12/2003
2Hypertrophy
10/2013 - 05/2013
2Ventricular Remodeling
11/2011 - 08/2011
2Coronary Disease (Coronary Heart Disease)
05/2010 - 06/2006
2Unstable Angina
07/2009 - 10/2002
2Hepatocellular Carcinoma (Hepatoma)
08/2008 - 01/2007
2Stable Angina
12/2007 - 09/2005
2Vascular Diseases (Vascular Disease)
09/2004 - 10/2002
1Reperfusion Injury
07/2015
1Vascular System Injuries
07/2015

Drug/Important Bio-Agent (IBA)

21Plasminogen Activator Inhibitor 1IBA
12/2013 - 08/2002
17Insulin (Novolin)FDA Link
01/2016 - 10/2002
16Plasminogen InactivatorsIBA
11/2012 - 11/2003
6Proteins (Proteins, Gene)FDA Link
08/2016 - 08/2002
5Plasminogen Activators (Plasminogen Activator)IBA
10/2013 - 06/2003
5Creatine Kinase (Creatine Phosphokinase)IBA
10/2013 - 07/2006
4Hydroxyproline (4 Hydroxyproline)IBA
10/2013 - 08/2004
4Biomarkers (Surrogate Marker)IBA
08/2011 - 12/2007
4CytokinesIBA
08/2011 - 01/2004
4Tissue Plasminogen Activator (Alteplase)FDA Link
01/2010 - 06/2004
4Fibrinogen (Factor I)FDA Link
01/2010 - 07/2004
4ErythropoietinFDA Link
10/2009 - 11/2007
4P-SelectinIBA
05/2009 - 12/2003
4ThrombinFDA Link
05/2009 - 07/2004
4Eptifibatide (Integrilin)FDA Link
03/2009 - 07/2005
3Conditioned Culture MediaIBA
07/2015 - 12/2013
3Pharmaceutical PreparationsIBA
10/2013 - 12/2008
3Angiotensin Receptor AntagonistsIBA
10/2013 - 08/2011
3Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/2011 - 07/2003
3Fibrinolytic Agents (Antithrombotic Agents)IBA
12/2010 - 07/2004
3ImmunosorbentsIBA
08/2010 - 08/2002
3EnzymesIBA
08/2010 - 08/2002
3Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
05/2010 - 09/2007
3TenecteplaseFDA Link
10/2009 - 06/2004
3Glucose (Dextrose)FDA LinkGeneric
07/2009 - 12/2003
3bivalirudin (Angiomax)FDA Link
03/2009 - 06/2002
3Interleukin-6 (Interleukin 6)IBA
01/2007 - 08/2005
3LipidsIBA
06/2006 - 10/2002
3Tirofiban (Aggrastat)FDA Link
02/2006 - 06/2002
3Heparin (Liquaemin)FDA LinkGeneric
09/2005 - 12/2004
3Enoxaparin (Lovenox)FDA LinkGeneric
06/2004 - 06/2002
2SphingosineIBA
08/2016 - 12/2013
2LigandsIBA
07/2015 - 03/2014
2Messenger RNA (mRNA)IBA
12/2013 - 03/2005
2azilsartan medoxomilIBA
05/2013 - 08/2011
2AntigensIBA
01/2010 - 02/2005
2fibrin fragment D (D-dimer)IBA
01/2010 - 12/2007
2ApolipoproteinsIBA
11/2009 - 05/2005
2Pioglitazone (Actos)FDA Link
09/2007 - 05/2005
2ThiazolidinedionesIBA
09/2007 - 04/2004
2Adenosine Diphosphate (ADP)IBA
02/2006 - 07/2005
2Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
09/2005 - 05/2004
2C-Reactive ProteinIBA
09/2005 - 08/2005
2Chromogenic CompoundsIBA
02/2005 - 08/2002
2CD40 Ligand (CD40L)IBA
12/2004 - 01/2004
2FibrinIBA
12/2004 - 07/2004
2Phenobarbital (Luminal)FDA Link
09/2004 - 07/2004
1Sphingosine-1-Phosphate ReceptorsIBA
08/2016
1ElementsIBA
08/2016
1sphingosine kinaseIBA
08/2016
1Transcription Factors (Transcription Factor)IBA
08/2016
1AdipokinesIBA
01/2016
1Immunoglobulin G (IgG)IBA
07/2015
1cytidylyl-(3'-5')-cytidine (CpC)IBA
03/2014
1Peptides (Polypeptides)IBA
03/2014
1sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
12/2013
1LyasesIBA
12/2013

Therapy/Procedure

9Therapeutics
07/2015 - 12/2004
6Percutaneous Coronary Intervention
09/2005 - 10/2002
3Glycemic Control
07/2009 - 10/2002
3Ligation
06/2009 - 07/2006
2Lasers (Laser)
08/2008 - 07/2002
2Renal Dialysis (Hemodialysis)
06/2007 - 08/2002
2Stents
04/2005 - 12/2004